Document Detail


MicroRNAs in metabolic disease.
MedLine Citation:
PMID:  23325474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alterations in the metabolic control of lipid and glucose homeostasis predispose an individual to develop cardiometabolic diseases, such as type 2-diabetes mellitus and atherosclerosis. Work over the last years has suggested that microRNAs (miRNAs) play an important role in regulating these physiological processes. The contribution of miRNAs in regulating metabolism is exemplified by miR-33, an intronic miRNA encoded in the Srebp genes. miR-33 controls cellular cholesterol export and fatty acid degradation, whereas its host genes stimulate cholesterol and fatty acid synthesis. Other miRNAs, such as miR-122, also play a critical role in regulating lipid homeostasis by controlling cholesterol synthesis and lipoprotein secretion in the liver. This review article summarizes the recent findings in the field, highlighting the contribution of miRNAs in regulating lipid and glucose metabolism. We will also discuss how the modulation of specific miRNAs may be a promising strategy to treat metabolic diseases.
Authors:
Carlos Fernández-Hernando; Cristina M Ramírez; Leigh Goedeke; Yajaira Suárez
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  33     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-14     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Metabolism / genetics
Gene Expression Regulation
Genetic Therapy
Glucose / metabolism
Homeostasis / genetics
Humans
Insulin / metabolism
Lipid Metabolism / genetics
Metabolic Diseases / genetics*,  metabolism,  therapy
MicroRNAs / metabolism*
Signal Transduction / genetics
Grant Support
ID/Acronym/Agency:
R01 HL105945/HL/NHLBI NIH HHS; R01 HL106063/HL/NHLBI NIH HHS; R01 HL107953/HL/NHLBI NIH HHS; R01HL105945/HL/NHLBI NIH HHS; R01HL106063/HL/NHLBI NIH HHS; R01HL107953/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; 0/MIRN122 microRNA, human; 0/MIRN33 microRNA, human; 0/MIRN375 microRNA, human; 0/MicroRNAs; IY9XDZ35W2/Glucose
Comments/Corrections

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