| MicroRNAs in immune response and macrophage polarization. | |
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MedLine Citation:
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PMID: 23325473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation is essential to combat invading microbial pathogens. In this process, the involvement of multiple immune cell populations is crucial in mounting an optimum immune response. In the past decade, a new class of noncoding small RNAs, called microRNAs (miRNAs), has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response is highlighted by studies in which deregulation of miRNAs was demonstrated to accompany diseases associated with excessive or uncontrolled inflammation. In this brief review, we summarize the roles of miRNAs that have been characterized in innate and adaptive immune responses. We discuss the role of miRNAs in macrophage polarization, a molecular event that has clear effect on inflammation. |
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Authors:
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Gang Liu; Edward Abraham |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 33 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-17 Completed Date: 2013-03-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 170-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. gliu@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity
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genetics* Animals Cell Differentiation Gene Expression Regulation Genotype Humans Immunity, Innate / genetics* Inflammation / genetics*, immunology Macrophage Activation / genetics* Macrophages / immunology, metabolism* MicroRNAs / metabolism* Phenotype Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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HL076206/HL/NHLBI NIH HHS; HL097218/HL/NHLBI NIH HHS; HL105473/HL/NHLBI NIH HHS; R01 HL076206/HL/NHLBI NIH HHS; R01 HL105473/HL/NHLBI NIH HHS; R21 HL097218/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
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