Document Detail


MicroRNAs in immune response and macrophage polarization.
MedLine Citation:
PMID:  23325473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation is essential to combat invading microbial pathogens. In this process, the involvement of multiple immune cell populations is crucial in mounting an optimum immune response. In the past decade, a new class of noncoding small RNAs, called microRNAs (miRNAs), has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response is highlighted by studies in which deregulation of miRNAs was demonstrated to accompany diseases associated with excessive or uncontrolled inflammation. In this brief review, we summarize the roles of miRNAs that have been characterized in innate and adaptive immune responses. We discuss the role of miRNAs in macrophage polarization, a molecular event that has clear effect on inflammation.
Authors:
Gang Liu; Edward Abraham
Related Documents :
23867903 - Formononetin potentiates epirubicin-induced apoptosis via ros production in hela cells ...
21171673 - Tofacitinib.
23867903 - Formononetin potentiates epirubicin-induced apoptosis via ros production in hela cells ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  33     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  170-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity / genetics*
Animals
Cell Differentiation
Gene Expression Regulation
Genotype
Humans
Immunity, Innate / genetics*
Inflammation / genetics*,  immunology
Macrophage Activation / genetics*
Macrophages / immunology,  metabolism*
MicroRNAs / metabolism*
Phenotype
Signal Transduction
Grant Support
ID/Acronym/Agency:
HL076206/HL/NHLBI NIH HHS; HL097218/HL/NHLBI NIH HHS; HL105473/HL/NHLBI NIH HHS; R01 HL076206/HL/NHLBI NIH HHS; R01 HL105473/HL/NHLBI NIH HHS; R21 HL097218/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of muscle acetylcholine receptor turnover by ? subunit tyrosine phosphorylation.
Next Document:  MicroRNAs in metabolic disease.