| MicroRNAs in Heart Development. | |
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MedLine Citation:
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PMID: 22449848 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length which are involved in the regulation of gene expression at the posttranscriptional level by degrading their target mRNAs and/or inhibiting their translation. Expressed ubiquitously or in a tissue-specific manner, miRNAs are involved in the regulation of many biological processes such as cell proliferation, differentiation, apoptosis, and the maintenance of normal cellular physiology. Many miRNAs are expressed in embryonic, postnatal, and adult hearts. Aberrant expression or genetic deletion of miRNAs is associated with abnormal cardiac cell differentiation, disruption of heart development, and cardiac dysfunction. This chapter will summarize the history, biogenesis, and processing of miRNAs as well as their function in heart development, remodeling, and disease. |
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Authors:
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Ramón A Espinoza-Lewis; Da-Zhi Wang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current topics in developmental biology Volume: 100 ISSN: 1557-8933 ISO Abbreviation: Curr. Top. Dev. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0163114 Medline TA: Curr Top Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 279-317 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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