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MicroRNAs in Heart Development.
MedLine Citation:
PMID:  22449848     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length which are involved in the regulation of gene expression at the posttranscriptional level by degrading their target mRNAs and/or inhibiting their translation. Expressed ubiquitously or in a tissue-specific manner, miRNAs are involved in the regulation of many biological processes such as cell proliferation, differentiation, apoptosis, and the maintenance of normal cellular physiology. Many miRNAs are expressed in embryonic, postnatal, and adult hearts. Aberrant expression or genetic deletion of miRNAs is associated with abnormal cardiac cell differentiation, disruption of heart development, and cardiac dysfunction. This chapter will summarize the history, biogenesis, and processing of miRNAs as well as their function in heart development, remodeling, and disease.
Authors:
Ramón A Espinoza-Lewis; Da-Zhi Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current topics in developmental biology     Volume:  100     ISSN:  1557-8933     ISO Abbreviation:  Curr. Top. Dev. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0163114     Medline TA:  Curr Top Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-317     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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