Document Detail


MicroRNAs in the Brain: It's Regulatory Role in Neuroinflammation.
MedLine Citation:
PMID:  23315269     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are single-stranded noncoding regions of approximately 21 nucleotides that regulate protein synthesis by targeting mRNAs for translational repression or degradation at the post-transcriptional level. These classes of RNAs are highly conserved across species and are known to regulate several protein-coding genes in humans. Therefore, their dysregulation is synonymous with inflammation, autoimmunity, neurodegeneration, viral infections, heart diseases, and cancer, among other conditions. Recent years have witnessed considerable amount of research interest in studies on miRNA-mediated modulation of gene function during neuroinflammation. This review is a meticulous compilation of information on biogenesis of miRNAs and their role in neuroinflammatory diseases. Further, their potential as markers of inflammatory diseases or novel therapeutic agents against neuroinflammation has also been discussed in detail.
Authors:
Menaka C Thounaojam; Deepak K Kaushik; Anirban Basu
Related Documents :
16714359 - Angiotensin ii-mediated oxidative stress and procollagen-1 expression in cardiac fibrob...
20978179 - Antenatal maternal hypoxic stress: adaptations in fetal lung renin-angiotensin system.
23460909 - A deep sequencing approach to uncover the mirnome in the human heart.
8952539 - Early expression of all the components of the renin-angiotensin-system in human develop...
23223429 - Simvastatin and t-butylhydroquinone suppress klf1 and bcl11a gene expression and additi...
8013389 - Regulation by growth factors of angiotensin ii type-1 receptor and the alpha subunit of...
12438259 - Characterization of a tissue-specific cdp/cux isoform, p75, activated in breast tumor c...
25429749 - Characteristics of pvt1 and its roles in diseases(△).
23743199 - Ngf induces adult stem leydig cells to proliferate and differentiate during leydig cell...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-12
Journal Detail:
Title:  Molecular neurobiology     Volume:  -     ISSN:  1559-1182     ISO Abbreviation:  Mol. Neurobiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900963     Medline TA:  Mol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National Brain Research Centre, Manesar, Haryana, 122050, India, menakachanu@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exome Sequencing Identified NRG3 as a Novel Susceptible Gene of Hirschsprung's Disease in a Chinese ...
Next Document:  Neuroprotective Effects of Resveratrol Against A? Administration in Rats are Improved by Lipid-Core ...