| MicroRNAs grow up in the immune system. | |
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MedLine Citation:
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PMID: 18554884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MicroRNA (miRNA) target predictions support a view in which each miRNA regulates translation and stability of several hundred messenger RNAs (mRNAs). Studies that overexpress individual miRNAs typically uncover relative subtle inhibition of the predicted targets. Accordingly, most miRNAs expressed in a given cell type may serve the function to broadly inhibit cell-type-inappropriate gene expression and deepen a pre-existing differentiation program. However, recent functional analyses of miRNAs in the immune system reveal that many cellular decisions are controlled by single miRNAs that entail significant downregulation of one or few target proteins. Investigations of these miRNA/mRNA pairs showed that miRNA-adjusted target protein levels are crucial at specific cellular transition points. Here, we will review recent advances in the regulation of the miRNA pathway and discuss how miRNAs control immune functions. |
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Authors:
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Kai P Hoefig; Vigo Heissmeyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-06-12 |
Journal Detail:
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Title: Current opinion in immunology Volume: 20 ISSN: 0952-7915 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-25 Completed Date: 2008-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 281-7 Citation Subset: IM |
Affiliation:
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Helmholtz Center Munich, Institute of Molecular Immunology, Marchioninistr. 25, 81377 Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin / metabolism Gene Expression Regulation Hematopoiesis / genetics Humans Lymphocyte Activation Lymphocytes / immunology* MicroRNAs / biosynthesis, genetics*, physiology* RNA Editing RNA Processing, Post-Transcriptional Transcription Factors / genetics Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/MicroRNAs; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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