Document Detail


MicroRNAs grow up in the immune system.
MedLine Citation:
PMID:  18554884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNA (miRNA) target predictions support a view in which each miRNA regulates translation and stability of several hundred messenger RNAs (mRNAs). Studies that overexpress individual miRNAs typically uncover relative subtle inhibition of the predicted targets. Accordingly, most miRNAs expressed in a given cell type may serve the function to broadly inhibit cell-type-inappropriate gene expression and deepen a pre-existing differentiation program. However, recent functional analyses of miRNAs in the immune system reveal that many cellular decisions are controlled by single miRNAs that entail significant downregulation of one or few target proteins. Investigations of these miRNA/mRNA pairs showed that miRNA-adjusted target protein levels are crucial at specific cellular transition points. Here, we will review recent advances in the regulation of the miRNA pathway and discuss how miRNAs control immune functions.
Authors:
Kai P Hoefig; Vigo Heissmeyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-06-12
Journal Detail:
Title:  Current opinion in immunology     Volume:  20     ISSN:  0952-7915     ISO Abbreviation:  Curr. Opin. Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900118     Medline TA:  Curr Opin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  IM    
Affiliation:
Helmholtz Center Munich, Institute of Molecular Immunology, Marchioninistr. 25, 81377 Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatin / metabolism
Gene Expression Regulation
Hematopoiesis / genetics
Humans
Lymphocyte Activation
Lymphocytes / immunology*
MicroRNAs / biosynthesis,  genetics*,  physiology*
RNA Editing
RNA Processing, Post-Transcriptional
Transcription Factors / genetics
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Chromatin; 0/MicroRNAs; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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