| MicroRNAs, fibrotic remodeling, and aortic aneurysms. | |
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MedLine Citation:
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PMID: 22269322 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aortic aneurysms are a common clinical condition that can cause death due to aortic dissection or rupture. The association between aortic aneurysm pathogenesis and altered TGF-β signaling has been the subject of numerous investigations. Recently, a TGF-β-responsive microRNA (miR), miR-29, has been identified to play a role in cellular phenotypic modulation during aortic development and aging. In this issue of JCI, Maegdefessel and colleagues demonstrate that decreasing the levels of miR-29b in the aortic wall can attenuate aortic aneurysm progression in two different mouse models of abdominal aortic aneurysms. This study highlights the relevance of miR-29b in aortic disease but also raises questions about its specific role. |
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Authors:
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Dianna M Milewicz |
Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-24 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-01 Completed Date: 2012-04-20 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 490-3 Citation Subset: AIM; IM |
Affiliation:
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Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA. dianna.m.milewicz@uth.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneurysm, Ruptured
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prevention & control* Animals Aortic Aneurysm, Abdominal / therapy* Humans Male MicroRNAs / antagonists & inhibitors*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/MIRN29 microRNA, human; 0/MIRN29 microRNA, mouse; 0/MicroRNAs |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2012 Feb 1;122(2):497-506
[PMID:
22269326
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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