Document Detail

MicroRNAs, fibrotic remodeling, and aortic aneurysms.
MedLine Citation:
PMID:  22269322     Owner:  NLM     Status:  MEDLINE    
Aortic aneurysms are a common clinical condition that can cause death due to aortic dissection or rupture. The association between aortic aneurysm pathogenesis and altered TGF-β signaling has been the subject of numerous investigations. Recently, a TGF-β-responsive microRNA (miR), miR-29, has been identified to play a role in cellular phenotypic modulation during aortic development and aging. In this issue of JCI, Maegdefessel and colleagues demonstrate that decreasing the levels of miR-29b in the aortic wall can attenuate aortic aneurysm progression in two different mouse models of abdominal aortic aneurysms. This study highlights the relevance of miR-29b in aortic disease but also raises questions about its specific role.
Dianna M Milewicz
Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-24
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-01     Completed Date:  2012-04-20     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-3     Citation Subset:  AIM; IM    
Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
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MeSH Terms
Aneurysm, Ruptured / prevention & control*
Aortic Aneurysm, Abdominal / therapy*
MicroRNAs / antagonists & inhibitors*,  metabolism*
Reg. No./Substance:
0/MIRN29 microRNA, human; 0/MIRN29 microRNA, mouse; 0/MicroRNAs
Comment On:
J Clin Invest. 2012 Feb 1;122(2):497-506   [PMID:  22269326 ]

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