Document Detail


MicroRNAs expression in chronic lymphocytic leukemia developing autoimmune hemolytic anemia.
MedLine Citation:
PMID:  23286334     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Chronic lymphocytic leukemia (CLL) is frequently associated with autoimmune hemolytic anemia (AIHA). However, the mechanisms governing the association between CLL and AIHA are poorly understood. miRNAS have been associated with different clinico-biological forms of CLL and are also known to play a substantial role in autoimmunity. However, there are no studies correlating miRNAs expression with the likelihood that patients with CLL will develop AIHA. In this study, we found that malignant B- cells from patients with CLL subsequently developing AIHA present nine downregulated (i.e., miR-19a, miR-20a, miR-29c miR-146b-5p, miR-186, miR-223 miR-324-3p, miR-484 and miR-660) miRNAs. Interestingly, two of these miRNAs (i.e., miR-20a and miR-146b-5p) are involved in autoimmune phenomena, and one (i.e., miR-146b-5p) in both autoimmunity and CLL. Furthermore, we demonstrate that miR-146b-5p modulates CD80, a molecule associated with the B-T-cell synapse and in restoring the antigen presenting capacity of CLL cells.
Authors:
Gerardo Ferrer; Alfons Navarro; Kate Hodgson; Marta Aymerich; Arturo Pereira; Tycho Baumann; Mariano Monzo; Carol Moreno; Emili Montserrat
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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