Document Detail

MicroRNAs and esophageal squamous cell carcinoma.
MedLine Citation:
PMID:  20588024     Owner:  NLM     Status:  MEDLINE    
Esophageal cancer is a common cause of cancer death worldwide. Esophageal squamous cell carcinoma (ESCC) is the most predominant type. Certain microRNAs (miRNAs) function in tumorgenesis involved in important biological and pathologic processes. To reveal miRNAs' signatures of ESCC, we analyzed miRNAs extracted from ESCC cell lines with the microRNA microarray. The significant alterations were confirmed by quantitative real-time PCR using miRNAs extracted from cell lines or patients' esophageal biopsy tissues. We found that miR-205 and miR-10a were significantly altered in cellular expression, and might be specific for ESCC with potential roles in the pathogenesis. As a result of function studies in miR-205, alterations in miR-205 expression could modulate the phenotype of epithelial cells towards epithelial-mesenchymal transition characterized by reduced abundance of E-cadherin, that is the ESCC-specific miRNA target and inhibit translationally a representative E-cadherin repressor, ZEB1 and ZEB2. Similarly, miR-10a is reported as a tumor suppressor by controlling cell migration/invasion, as it can target homeobox genes. These results provide insight into the potential mechanisms of ESCC in the pathogenesis. This review also includes a comprehensive overview of the relationship between miRNAs and ESCC.
Kayoko Matsushima; Hajime Isomoto; Shigeru Kohno; Kazuhiko Nakao
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-06-25
Journal Detail:
Title:  Digestion     Volume:  82     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  138-44     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki 852-8501, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / metabolism*
Cell Line, Tumor
Cell Physiological Processes
Esophageal Neoplasms / metabolism*
MicroRNAs / metabolism*
Reg. No./Substance:
0/MIRN10 microRNA, human; 0/MIRN205 microRNA, human; 0/MicroRNAs

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