| MicroRNAs and cell cycle regulation. | |
| | |
MedLine Citation:
|
PMID: 17786041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
MicroRNAs (microRNAs) are abundant, approximately 21-25 nucleotide (nt) non-coding RNAs that mediate sequence-specific, post-transcriptional repression of mRNA targets. Emerging evidence suggests that several microRNAs target transcripts that encode proteins directly or indirectly involved in cell cycle progression and cellular proliferation. Moreover, alteration of microRNA levels can contribute to pathological conditions, including tumorigenesis, that are associated with loss of cell cycle control. In this review we highlight recent data linking microRNAs to mammalian cell cycle regulation. We describe how specific miRNAs function within pathways that control cell cycle checkpoints. We discuss emerging evidence that support the idea that some microRNA activity may be cell cycle dependent, and we outline how the coordinate regulation of microRNA targets may influence cell cycle progression. |
| | |
Authors:
|
Michael Carleton; Michele A Cleary; Peter S Linsley |
Publication Detail:
|
Type: Journal Article; Review Date: 2007-06-26 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 6 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-09-20 Completed Date: 2007-10-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 2127-32 Citation Subset: IM |
Affiliation:
|
Rosetta Inpharmatics LLC, Seattle, Washington 98109, USA. michael_carleton@merck.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis Cell Cycle / genetics* Cell Differentiation Humans MicroRNAs / genetics, metabolism* Neoplasms / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
|
0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: mDia function is critical for the cell suicide program triggered by farnesyl transferase inhibition.
Next Document: Nutlin-3 inhibits the NFkappaB pathway in a p53-dependent manner: implications in lung cancer therap...