Document Detail

MicroRNAs within the continuum of postgenomics biomarker discovery.
MedLine Citation:
PMID:  23325478     Owner:  NLM     Status:  MEDLINE    
The postgenomic shift in paradigm from reductionism to systems-wide network inference has increased recognition that cardiovascular diseases are not simply determined by the genome but arise from an interaction and dynamic dysregulation of gene regulatory networks, proteins, and metabolic alterations. The advent of postgenomic technologies promises to interrogate these complex pathophysiological perturbations by applying concepts of systemic relationships to biomarker discovery. A multibiomarker panel consisting of biomarkers capturing different levels of information (eg, microRNAs to assess endothelial and platelet activation, molecular lipid species to profile metabolic status, and proteolytic degradation products to assess vascular integrity) could outperform inflammatory biomarkers without vascular specificity in their ability of predicting cardiovascular risk. As atherosclerosis develops over decades, different biomarkers may be required for different stages of disease. Thus far, there is no simple blood test to directly assess the health of blood vessels or identify vulnerable patients. We discuss strategies for biomarker discovery using post genomics technologies, with a particular focus on circulating microRNAs. The aim is to reveal distinctive cardiovascular phenotypes and identify biomarker signatures that complement the Framingham risk scores in clinical decision-making and in a stratified medicine approach for early preventive treatment of disease.
Manuel Mayr; Anna Zampetaki; Peter Willeit; Johann Willeit; Stefan Kiechl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  33     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-14     Revised Date:  2014-06-18    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-14     Citation Subset:  IM    
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MeSH Terms
Blood Proteins / analysis
Cardiovascular Diseases / blood,  diagnosis,  genetics*,  therapy
Gene Expression Regulation
Genetic Markers
Genetic Predisposition to Disease
Genetic Testing* / methods
Genomics* / methods
Lipids / blood
MicroRNAs / blood,  metabolism*
Predictive Value of Tests
Reproducibility of Results
Risk Assessment
Risk Factors
Systems Biology* / methods
Grant Support
FS/13/2/29892//British Heart Foundation; SP/12/5/29574//British Heart Foundation; //British Heart Foundation
Reg. No./Substance:
0/Blood Proteins; 0/Genetic Markers; 0/Lipids; 0/MicroRNAs

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