| MicroRNAs and Type 2 Diabetes/Obesity. | |
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MedLine Citation:
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PMID: 22293113 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications. |
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Authors:
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Mustafa Abdo Saif Dehwah; Aimin Xu; Qingyang Huang |
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Publication Detail:
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Type: Journal Article Date: 2011-12-29 |
Journal Detail:
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Title: Journal of genetics and genomics = Yi chuan xue bao Volume: 39 ISSN: 1673-8527 ISO Abbreviation: J Genet Genomics Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101304616 Medline TA: J Genet Genomics Country: China |
Other Details:
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Languages: eng Pagination: 11-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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