Document Detail


MicroRNAs and glial cell development.
MedLine Citation:
PMID:  21555783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mounting evidence indicates that microRNAs (miRNAs) play important roles in the control of glial cell development in the central nervous system. Suppression of miRNA formation disrupts the initial generation of oligodendrocyte progenitor cells from the ventricular neuroprogenitor cells in the embryonic spinal cord. miRNAs also regulate the later events of oligodendrocyte development, including cell proliferation, maturation, and myelin formation. In addition, miRNAs are essential for the development of astrocytes, and inhibition of miRNA genesis completely blocks astrogliogenesis in the spinal cord.
Authors:
Kang Zheng; Hong Li; Hao Huang; Mengsheng Qiu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-05-09
Journal Detail:
Title:  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry     Volume:  18     ISSN:  1089-4098     ISO Abbreviation:  Neuroscientist     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-07-26     Revised Date:  2013-09-10    
Medline Journal Info:
Nlm Unique ID:  9504819     Medline TA:  Neuroscientist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-8     Citation Subset:  IM    
Affiliation:
Institute of Developmental and Regenerative Biology, Hangzhou Normal University, College of Life and Environmental Sciences, Hangzhou, Zhejiang, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / physiology
Cell Differentiation / physiology
Cell Proliferation
Gene Expression Regulation, Developmental
Humans
MicroRNAs / physiology*
Myelin Sheath / physiology
Neuroglia / physiology*
Oligodendroglia / physiology
Spinal Cord / cytology,  physiology
Grant Support
ID/Acronym/Agency:
NS37717/NS/NINDS NIH HHS; R01 NS037717/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs
Comments/Corrections

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