| MicroRNAs both promote and antagonize longevity in C. elegans. | |
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MedLine Citation:
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PMID: 21129974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: aging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span. RESULTS: here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most upregulated miRNAs lead to life-span defects. Some act to promote normal life span and stress resistance, whereas others inhibit these phenomena. We find that these miRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insulin signaling pathway. CONCLUSIONS: our findings reveal that miRNAs both positively and negatively influence life span. Because several miRNAs upregulated during aging regulate genes in conserved pathways of aging and thereby influence life span in C. elegans, we propose that miRNAs may play important roles in stress response and aging of more complex organisms. |
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Authors:
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Alexandre de Lencastre; Zachary Pincus; Katherine Zhou; Masaomi Kato; Siu Sylvia Lee; Frank J Slack |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-02 |
Journal Detail:
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Title: Current biology : CB Volume: 20 ISSN: 1879-0445 ISO Abbreviation: Curr. Biol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-21 Completed Date: 2011-04-04 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: England |
Other Details:
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Languages: eng Pagination: 2159-68 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511 USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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genetics Animals Base Sequence Caenorhabditis elegans / genetics*, physiology* Humans Insulin-Like Growth Factor I / physiology Longevity / genetics*, physiology MicroRNAs / chemistry, genetics*, metabolism* Molecular Sequence Data Nucleic Acid Conformation Sequence Alignment Sequence Analysis, RNA Signal Transduction / physiology Stress, Physiological |
| Grant Support | |
ID/Acronym/Agency:
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1F32AG030851/AG/NIA NIH HHS; AG033921/AG/NIA NIH HHS; R01 AG033921-08/AG/NIA NIH HHS; R01 AG033921-09/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
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