Document Detail


MicroRNAs-140-5p/140-3p Modulate Leydig Cell Numbers in the Developing Mouse Testis.
MedLine Citation:
PMID:  23616593     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) have been shown to play key regulatory roles in a range of biological processes, including cell differentiation and development. To identify miRNAs that participate in gonad differentiation, a fundamental and tightly regulated developmental process, we examined miRNA expression profiles at the time of sex determination and during the early fetal differentiation of mouse testes and ovaries using high-throughput sequencing. We identified several miRNAs that were expressed in a sexually dimorphic pattern, including several members of the let-7 family, miR-378 and miR-140-3p. We focused our analysis on the most highly expressed sexually dimorphic miRNA, miR-140-3p, and found that both miR-140-3p and its more lowly expressed counterpart, the previously annotated guide strand, miR-140-5p, are testis-enriched and expressed in testis cords. Analysis of the miR-140-5p/miR-140-3p null mouse revealed a significant increase in the number of Leydig cells in the developing XY gonad, strongly suggesting an important role for miR-140-5p/miR-140-3p in testis differentiation in mouse.
Authors:
Joanna Rakoczy; Selene L Fernandez-Valverde; Evgeny A Glazov; Elanor N Wainwright; Tempei Sato; Shuji Takada; Alexander N Combes; Darren J Korbie; David Miller; Sean M Grimmond; Melissa H Little; Hiroshi Asahara; John S Mattick; Ryan J Taft; Dagmar Wilhelm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-24
Journal Detail:
Title:  Biology of reproduction     Volume:  -     ISSN:  1529-7268     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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