Document Detail


MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction.
MedLine Citation:
PMID:  20886220     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here for the first time whole-genome miRNA expression in peripheral total blood samples of patients with acute myocardial infarction (AMI). We identified 121 miRNAs, which are significantly dysregulated in AMI patients in comparison to healthy controls. Among these, miR-1291 and miR-663b show the highest sensitivity and specificity for the discrimination of cases from controls. Using a novel self-learning pattern recognition algorithm, we identified a unique signature of 20 miRNAs that predicts AMI with even higher power (specificity 96%, sensitivity 90%, and accuracy 93%). In addition, we show that miR-30c and miR-145 levels correlate with infarct sizes estimated by Troponin T release. The here presented study shows that single miRNAs and especially miRNA signatures derived from peripheral blood, could be valuable novel biomarkers for cardiovascular diseases.
Authors:
Benjamin Meder; Andreas Keller; Britta Vogel; Jan Haas; Farbod Sedaghat-Hamedani; Elham Kayvanpour; Steffen Just; Anne Borries; Jessica Rudloff; Petra Leidinger; Eckart Meese; Hugo A Katus; Wolfgang Rottbauer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-01
Journal Detail:
Title:  Basic research in cardiology     Volume:  106     ISSN:  1435-1803     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  13-23     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gender differences in radical nephroureterectomy for upper tract urothelial carcinoma.
Next Document:  Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of...