Document Detail

MicroRNA role in thyroid cancer pathogenesis.
MedLine Citation:
PMID:  23276957     Owner:  NLM     Status:  MEDLINE    
MicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs approximately 22 nucleotides in length that negatively regulate translation of the protein-coding genes. As such, miRNAs are fundamental mediators of cellular differentiation, proliferation, and survival. Each miRNA may functionally interact with a multitude of target genes to exert various effects on normal physiology to support human health or pathological processes leading to disease conditions, such as cancer. Genome-wide analyses have generated specific miRNA profiles of thyroid cancers (TCs) and identified the up- and down-regulated miRNAs related to various carcinogenesis stages and prognoses. Here, we summarize the recent knowledge on aberrant miRNA expression in the various TCs, including papillary, follicular, and other rare types. In addition, we discuss the significance of miRNA profiles and individual miRNAs in the diagnosis, treatment, and prognosis of these tumors.
Xiaoping Zhang; Haian Mao; Zhongwei Lv
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  734-9     Citation Subset:  IM    
Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China.
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MeSH Terms
Adenocarcinoma, Follicular / genetics
Carcinoma / genetics
Genes, Tumor Suppressor
Histone Deacetylases / genetics
MicroRNAs / genetics*,  physiology
Oncogenes / physiology
Thyroid Neoplasms / diagnosis,  etiology,  genetics*,  pathology
Reg. No./Substance:
0/MIRN146 microRNA, human; 0/MicroRNAs; EC Deacetylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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