Document Detail


MicroRNA: a new frontier in kidney and blood pressure research.
MedLine Citation:
PMID:  19339633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNA (miRNA) has emerged rapidly as a major new direction in many fields of research including kidney and blood pressure research. A mammalian genome encodes several hundred miRNAs. These miRNAs potentially regulate the expression of thousands of proteins. miRNA expression profiles differ substantially between the kidney and other organs as well as between kidney regions. miRNAs may be functionally important in models of diabetic nephropathy, podocyte development, and polycystic disease. miRNAs may be involved in the regulation of arterial blood pressure, including possible involvement in genetic elements of hypertension. Studies of miRNAs could generate diagnostic biomarkers for kidney disease and new mechanistic insights into the complex regulatory networks underlying kidney disease and hypertension. Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation.
Authors:
Mingyu Liang; Yong Liu; Domagoj Mladinov; Allen W Cowley; Hariprasad Trivedi; Yi Fang; Xialian Xu; Xiaoqiang Ding; Zhongmin Tian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-04-01
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  297     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-09-08     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  F553-8     Citation Subset:  IM    
Affiliation:
Dept. of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. mliang@mcw.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / genetics*
Gene Expression Regulation
Genetic Markers
Humans
Hypertension / genetics*,  physiopathology
Kidney Diseases / genetics*,  physiopathology
MicroRNAs / metabolism*
Grant Support
ID/Acronym/Agency:
P01-HL-082798/HL/NHLBI NIH HHS; P01-HL-29587-23/HL/NHLBI NIH HHS; R01-HL-077263/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/MicroRNAs
Comments/Corrections

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