|MicroRNA microarray expression profiling in human myocardial infarction.|
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|PMID: 20075508 Owner: NLM Status: MEDLINE|
|MicroRNAs (miRNAs), small non-coding RNA molecules, are negative regulators of gene expression. Recent studies have indicated their role in various forms of cardiovascular disease. In spite of the number of miRNA microarray analyses performed, little is known about the genome-wide miRNA expression pattern in human myocardial infarction (MI).Using miRNA microarrays and bioinformatic analysis, miRNA expression was analyzed on human MI and foetal hearts compared to healthy adult hearts, to determine whether there is any similar expression pattern between MI and foetal hearts, and to identified miRNAs that have not previously been described as dysregulated in cardiovascular diseases. Of 719 miRNAs analyzed, approximately 50% were expressed in human hearts, 77 miRNAs were absent from all tested tissues and 57 were confidently dysregulated in at least one tested group. Some expression patterns appeared to be similar in MI and foetal hearts. Bioinformatic analysis revealed 10 miRNAs as dysregulated in MI not yet related to cardiovascular disease, and 5 miRNAs previously described only in animal models of cardiovascular diseases. Finally, qRT-PCR analysis confirmed dysregulation of 7 miRNAs, miR-150, miR-186, miR-210, miR-451, and muscle-specific, miR-1 and miR-133a/b; all of these are believed to be involved in various physiological and pathological processes.|
|Emanuela Bostjancic; Nina Zidar; Damjan Glavac|
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|Type: Journal Article; Research Support, Non-U.S. Gov't|
|Title: Disease markers Volume: 27 ISSN: 1875-8630 ISO Abbreviation: Dis. Markers Publication Date: 2009|
|Created Date: 2010-01-15 Completed Date: 2010-03-31 Revised Date: 2013-12-03|
Medline Journal Info:
|Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: Netherlands|
|Languages: eng Pagination: 255-68 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Aged, 80 and over
Biological Markers / metabolism
Fetal Heart / metabolism
Gene Expression Profiling
Gene Expression Regulation
MicroRNAs / biosynthesis*, genetics
Myocardial Infarction / metabolism*
Myocardium / metabolism
Oligonucleotide Array Sequence Analysis
|0/Biological Markers; 0/MIRN1 microRNA, human; 0/MIRN150 microRNA, human; 0/MIRN186 microRNA, human; 0/MIRN210 microRNA, human; 0/MIRN451 microRNA, human; 0/MicroRNAs|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
Publisher: IOS Press
Copyright © 2009 Hindawi Publishing Corporation.
Received Day: 6 Month: 1 Year: 2010
Accepted Day: 6 Month: 1 Year: 2010
Print publication date: Year: 2009
Electronic publication date: Day: 14 Month: 1 Year: 2010
Volume: 27 Issue: 6
First Page: 255 Last Page: 268
PubMed Id: 20075508
Article Id: 641082
|MicroRNA Microarray Expression Profiling in Human Myocardial Infarction|
|Department of Molecular GeneticsInstitute of PathologyFaculty of MedicineUniversity of LjubljanaSlovenia
|Correspondence: *Damjan Glavač: email@example.com
Keywords: MiRNA, microarray, myocardial infarction, expression.
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