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MicroRNA microarray expression profiling in human myocardial infarction.
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MedLine Citation:
PMID:  20075508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNAs (miRNAs), small non-coding RNA molecules, are negative regulators of gene expression. Recent studies have indicated their role in various forms of cardiovascular disease. In spite of the number of miRNA microarray analyses performed, little is known about the genome-wide miRNA expression pattern in human myocardial infarction (MI).Using miRNA microarrays and bioinformatic analysis, miRNA expression was analyzed on human MI and foetal hearts compared to healthy adult hearts, to determine whether there is any similar expression pattern between MI and foetal hearts, and to identified miRNAs that have not previously been described as dysregulated in cardiovascular diseases. Of 719 miRNAs analyzed, approximately 50% were expressed in human hearts, 77 miRNAs were absent from all tested tissues and 57 were confidently dysregulated in at least one tested group. Some expression patterns appeared to be similar in MI and foetal hearts. Bioinformatic analysis revealed 10 miRNAs as dysregulated in MI not yet related to cardiovascular disease, and 5 miRNAs previously described only in animal models of cardiovascular diseases. Finally, qRT-PCR analysis confirmed dysregulation of 7 miRNAs, miR-150, miR-186, miR-210, miR-451, and muscle-specific, miR-1 and miR-133a/b; all of these are believed to be involved in various physiological and pathological processes.
Authors:
Emanuela Bostjancic; Nina Zidar; Damjan Glavac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  27     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2009  
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-31     Revised Date:  2013-12-03    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  255-68     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Markers / metabolism
Female
Fetal Heart / metabolism
Gene Expression Profiling
Gene Expression Regulation
Humans
Male
MicroRNAs / biosynthesis*,  genetics
Middle Aged
Myocardial Infarction / metabolism*
Myocardium / metabolism
Oligonucleotide Array Sequence Analysis
Pregnancy
Chemical
Reg. No./Substance:
0/Biological Markers; 0/MIRN1 microRNA, human; 0/MIRN150 microRNA, human; 0/MIRN186 microRNA, human; 0/MIRN210 microRNA, human; 0/MIRN451 microRNA, human; 0/MicroRNAs

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2009 Hindawi Publishing Corporation.
Received Day: 6 Month: 1 Year: 2010
Accepted Day: 6 Month: 1 Year: 2010
Print publication date: Year: 2009
Electronic publication date: Day: 14 Month: 1 Year: 2010
Volume: 27 Issue: 6
First Page: 255 Last Page: 268
PubMed Id: 20075508
ID: 3834671
Article Id: 641082
DOI: 10.3233/DMA-2009-0671

MicroRNA Microarray Expression Profiling in Human Myocardial Infarction
Emanuela BoštjančičI1
Nina ZidarI1
Damjan GlavačI1*
Department of Molecular GeneticsInstitute of PathologyFaculty of MedicineUniversity of LjubljanaSlovenia
Correspondence: *Damjan Glavač: damjan.glavac@mf.uni-lj.si


Article Categories:
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Keywords: MiRNA, microarray, myocardial infarction, expression.

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