Document Detail


MicroRNA in the molecular mechanism of the circadian clock in mammals.
MedLine Citation:
PMID:  23276934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biochemical activity of mammals is controlled by an internal timekeeping mechanism driving a clock to run in approximate 24-hour (circadian) cycles. In mammals, this circadian clock is located both in the suprachiasmatic nuclei (SCN) and peripheral oscillators. Recently, microRNAs have emerged as significant players in circadian clock timing. The biological implications of miRNAs are extended further by recent studies that microRNAs are expressed in the SCN and peripheral circadian oscillators. In this study, we review recent work revealing the role of microRNAs in the molecular mechanism of circadian clock in mammals.
Authors:
Cheng Chu; Zhongxin Zhao
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
Affiliation:
Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Clocks / drug effects,  physiology*
Intestines / physiology
Mice
MicroRNAs / biosynthesis*,  physiology
Period Circadian Proteins / genetics,  physiology
Rats
Retina / physiology
Suprachiasmatic Nucleus / physiology*
Chemical
Reg. No./Substance:
0/MIRN132 microRNA, mouse; 0/MicroRNAs; 0/Period Circadian Proteins

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