Document Detail


MicroRNA expression in the embryonic mouse inner ear.
MedLine Citation:
PMID:  20467336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although microRNA (miRNA) is expressed extensively in the postnatal mouse inner ear, its expression in the sensory epithelium during embryogenesis has not been well characterized. We investigated miRNA expression at E13.5 and E16.5 by microarray analysis, quantitative real-time-PCR, and in-situ hybridization. MiRNA-182, miRNA-140, miRNA-200c, and others showed distinct temporal and spatial expression patterns. MiRNA-194, whose expression in zebrafish seems to play an important role in the differentiation of the intestinal epithelium, was also expressed in the spiral ganglia of the mouse inner ear, where it may play a similar role in neuronal differentiation. Our results indicate that miRNAs are widely expressed in the developing inner ear, with more species recruited as hair cells differentiate, suggesting an important developmental role.
Authors:
Xian-Ren Wang; Xue-Mei Zhang; Jing Zhen; Pen-Xing Zhang; Geng Xu; Hongyan Jiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  21     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-7     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Ear, Inner / embryology*,  metabolism*
In Situ Hybridization
Mice
Mice, Inbred C57BL
MicroRNAs / metabolism*
Models, Biological
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Software
Spiral Ganglion / embryology,  metabolism
Chemical
Reg. No./Substance:
0/MIRN140 microRNA, mouse; 0/MicroRNAs; 0/Mirn182 microRNA, mouse

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