| MicroRNA expression in the embryonic mouse inner ear. | |
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MedLine Citation:
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PMID: 20467336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although microRNA (miRNA) is expressed extensively in the postnatal mouse inner ear, its expression in the sensory epithelium during embryogenesis has not been well characterized. We investigated miRNA expression at E13.5 and E16.5 by microarray analysis, quantitative real-time-PCR, and in-situ hybridization. MiRNA-182, miRNA-140, miRNA-200c, and others showed distinct temporal and spatial expression patterns. MiRNA-194, whose expression in zebrafish seems to play an important role in the differentiation of the intestinal epithelium, was also expressed in the spiral ganglia of the mouse inner ear, where it may play a similar role in neuronal differentiation. Our results indicate that miRNAs are widely expressed in the developing inner ear, with more species recruited as hair cells differentiate, suggesting an important developmental role. |
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Authors:
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Xian-Ren Wang; Xue-Mei Zhang; Jing Zhen; Pen-Xing Zhang; Geng Xu; Hongyan Jiang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 21 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-03 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 611-7 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Ear, Inner / embryology*, metabolism* In Situ Hybridization Mice Mice, Inbred C57BL MicroRNAs / metabolism* Models, Biological Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Software Spiral Ganglion / embryology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/MIRN140 microRNA, mouse; 0/MicroRNAs; 0/Mirn182 microRNA, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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