Document Detail

MicroRNA control of vascular endothelial growth factor signaling output during vascular development.
MedLine Citation:
PMID:  23325476     Owner:  NLM     Status:  MEDLINE    
The regulated response of endothelial cells to signals in their environment is not only critical for the de novo formation of primordial vascular networks during early development (ie, vasculogenesis), but is also required for the subsequent growth and remodeling of new blood vessels from preexisting ones (ie, angiogenesis). Vascular endothelial growth factors (Vegfs) and their endothelial cell-specific receptors play a crucial role in nearly all aspects of blood vessel growth. How the outputs from these pathways affect and coordinate endothelial behavior is an area of intense research. Recently, numerous studies have highlighted roles for microRNAs in modulating Vegf signaling output in several different contexts. In this review, we will provide an overview of how small RNAs regulate multiple aspects of the Vegf signaling pathway. In particular, we highlight areas where identification of microRNAs and their targets has provided new insight into the role of downstream effectors in modulating Vegf output during development. As Vegf plays a broad role in multiple aspects of endothelial biology and has become a target for therapeutic manipulation of pathological blood vessel growth, microRNAs that affect Vegf signaling output will undoubtedly be major targets of clinical value.
Lan T H Dang; Nathan D Lawson; Jason E Fish
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  33     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
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MeSH Terms
Blood Vessels / embryology,  metabolism*
Endothelial Cells / metabolism*
Gene Expression Regulation, Developmental
Intracellular Signaling Peptides and Proteins / metabolism
MicroRNAs / metabolism*
Neovascularization, Physiologic* / genetics
Receptors, Vascular Endothelial Growth Factor / metabolism
Signal Transduction* / genetics
Vascular Endothelial Growth Factor A / genetics,  metabolism*
Grant Support
MOP-119506//Canadian Institutes of Health Research; R01 HL093467/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/MicroRNAs; 0/Vascular Endothelial Growth Factor A; EC, Vascular Endothelial Growth Factor

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