| MicroRNA-Based Therapeutic Approaches in the Cardiovascular System. | |
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MedLine Citation:
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PMID: 20946325 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MicroRNAs (miRNAs) are endogenous small ribonucleotides that participate in the orchestration of the genome by regulating target messenger RNA translation. MiRNAs control physiological processes and misexpression of miRNAs is pathogenically involved in many diseases including cardiovascular diseases. Normalization of miRNA expression and thus downstream target networks may have enormous therapeutic chances but also risks. We here highlight and discuss recent advances in the development and use of miRNA therapeutics to target miRNAs in vivo that may translate into novel therapeutic strategies for cardiovascular diseases in the future. |
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Authors:
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J Fiedler; S K Gupta; T Thum |
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Publication Detail:
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Type: Journal Article Date: 2010-10-14 |
Journal Detail:
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Title: Cardiovascular therapeutics Volume: 30 ISSN: 1755-5922 ISO Abbreviation: Cardiovasc Ther Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101319630 Medline TA: Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: e9-e15 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany Department of Cardiology and Angiology, Hannover Medical School, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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