Document Detail


MicroRNA-Based Therapeutic Approaches in the Cardiovascular System.
MedLine Citation:
PMID:  20946325     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MicroRNAs (miRNAs) are endogenous small ribonucleotides that participate in the orchestration of the genome by regulating target messenger RNA translation. MiRNAs control physiological processes and misexpression of miRNAs is pathogenically involved in many diseases including cardiovascular diseases. Normalization of miRNA expression and thus downstream target networks may have enormous therapeutic chances but also risks. We here highlight and discuss recent advances in the development and use of miRNA therapeutics to target miRNAs in vivo that may translate into novel therapeutic strategies for cardiovascular diseases in the future.
Authors:
J Fiedler; S K Gupta; T Thum
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Publication Detail:
Type:  Journal Article     Date:  2010-10-14
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  30     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  e9-e15     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany  Department of Cardiology and Angiology, Hannover Medical School, Germany.
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