Document Detail

MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-κB1 pathway.
MedLine Citation:
PMID:  22825752     Owner:  NLM     Status:  In-Data-Review    
The aggressive course of uveal melanoma is believed to reflect its unusually invasive and metastatic nature, which is associated with the nuclear factor kappaB (NF-κB) pathway. MicroRNAs (miRNAs) have been implicated in the regulation of various biological and pathological processes in cancer, however, the special role of miR-9 in uveal melanoma metastasis is largely unknown. In the present study, we showed that miR-9 is significantly reduced in highly invasive uveal melanoma cell lines, and suppressed migration and invasion of highly invasive cells. Furthermore, miR-9 negatively modulated NF-κB1 expression by direct targeting at its 3'-UTRs. Additionally, downstream targets of NF-κB1, such as MMP-2, MMP-9 and VEGFA, were regulated by miR-9 in the same pattern as NF-κB1. Therefore, miR-9 suppresses uveal melanoma cell migration and invasion partly through downregulation of the NF-κB1 signaling pathway.
Nannan Liu; Qingmin Sun; Jie Chen; Jiaqi Li; Ying Zeng; Sulan Zhai; Ping Li; Bin Wang; Xuerong Wang
Publication Detail:
Type:  Journal Article     Date:  2012-07-06
Journal Detail:
Title:  Oncology reports     Volume:  28     ISSN:  1791-2431     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  961-8     Citation Subset:  IM    
Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China.
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