| MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-κB1 pathway. | |
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MedLine Citation:
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PMID: 22825752 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aggressive course of uveal melanoma is believed to reflect its unusually invasive and metastatic nature, which is associated with the nuclear factor kappaB (NF-κB) pathway. MicroRNAs (miRNAs) have been implicated in the regulation of various biological and pathological processes in cancer, however, the special role of miR-9 in uveal melanoma metastasis is largely unknown. In the present study, we showed that miR-9 is significantly reduced in highly invasive uveal melanoma cell lines, and suppressed migration and invasion of highly invasive cells. Furthermore, miR-9 negatively modulated NF-κB1 expression by direct targeting at its 3'-UTRs. Additionally, downstream targets of NF-κB1, such as MMP-2, MMP-9 and VEGFA, were regulated by miR-9 in the same pattern as NF-κB1. Therefore, miR-9 suppresses uveal melanoma cell migration and invasion partly through downregulation of the NF-κB1 signaling pathway. |
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Authors:
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Nannan Liu; Qingmin Sun; Jie Chen; Jiaqi Li; Ying Zeng; Sulan Zhai; Ping Li; Bin Wang; Xuerong Wang |
Publication Detail:
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Type: Journal Article Date: 2012-07-06 |
Journal Detail:
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Title: Oncology reports Volume: 28 ISSN: 1791-2431 ISO Abbreviation: Oncol. Rep. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-07-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 961-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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