| MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. | |
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MedLine Citation:
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PMID: 21852381 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cancer pathogenesis is restricted by stresses that compromise cell division and survival. In this study we identify miR-708, a little studied member of a set of microRNAs that have been implicated in stress control, as an important suppressor function in renal cell carcinoma (RCC). miR-708 expression was attenuated widely in human RCC specimens. Restoration of miR-708 expression in RCC cell lines decreased cell growth, clonability, invasion and migration and elicited a dramatic increase in apoptosis. Moreover, intratumoral delivery of miR-708 was sufficient to trigger in vivo regression of established tumors in a murine xenograft models of human RCC. Investigation of the targets of miR-708 identified the inhibitor of apoptosis protein survivin as important. siRNA-mediated knockdown of survivin partially phenocopied miR-708 overexpression suggesting that the pro-apoptotic role of miR-708 may be mediated primarily through survivin regulation. Additionally, we identified the E-cadherin regulators ZEB2 and BMI1 as likely miR-708 targets. Taken together, our findings define a major tumor suppressive role for miR-708, which may offer an attractive new target for prognostic and therapeutic intervention in RCC. |
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Authors:
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Sharanjot Saini; Soichiro Yamamura; Shahana Majid; Varahram Shahryari; Hiroshi Hirata; Yuichiro Tanaka; Rajvir Dahiya |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: Cancer research Volume: - ISSN: 1538-7445 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UROLOGY, SFVAMC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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