Document Detail

MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.
MedLine Citation:
PMID:  19737067     Owner:  NLM     Status:  Publisher    
We identified that microRNA expression changed dynamically during liver development and found that miR-500 is an oncofetal miRNA in liver cancer. miR-500 was abundantly expressed in several human liver cancer cell lines and 45% of human hepatocellular carcinoma (HCC) tissue. Most importantly, an increased amount of miR-500 was found in the sera of the HCC patients. In fact, miR-500 levels in sera of the HCC patients returned to normal after the surgical treatment in three HCC patients. Our findings reveal that diverse changes of miRNAs occur during liver development and, one of these, miR-500 is an oncofetal miRNA relevant to the diagnosis of human HCC.
Yusuke Yamamoto; Nobuyoshi Kosaka; Minoru Tanaka; Fumiaki Koizumi; Yae Kanai; Takayuki Mizutani; Yoshiki Murakami; Masahiko Kuroda; Atsushi Miyajima; Takashi Kato; Takahiro Ochiya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-9-8
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  -     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Section for Studies on Metastasis, National Cancer Center Research Institute, 1-1, Tsukiji, 5-chome, Chuo-ku, Tokyo 104-0045, Japan.
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