| MicroRNA-16 targets zyxin and promotes cell motility in human laryngeal carcinoma cell line HEp-2. | |
| | |
MedLine Citation:
|
PMID: 21360639 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
MicroRNAs are small noncoding RNAs that negatively regulate target mRNAs at the posttranscription level. Here, we show that miR-16 is upregulated in human laryngeal carcinoma tissues. Inhibition of miR-16 in HEp-2 laryngeal cancer cell line could suppress cell migration and enhance cell-cell adhesion. Subsequently, zyxin, whose expression is negatively regulated by miR-16, is confirmed to be a direct target gene of miR-16. Furthermore, overexpression of zyxin could also restrain cell movement and enhance cell-cell adhesion. The study of miR-16 and its target zyxin will shed light on diagnosis and therapy of laryngeal cancer. © 2011 IUBMB IUBMB Life, 63(2): 101-108, 2011. |
| | |
Authors:
|
Haidong Wu; Tao Liu; Renjie Wang; Shuang Tian; Min Liu; Xin Li; Hua Tang |
Related Documents
:
|
3779849 - Multiple forms of acid phosphatase and their differential secretion during stalk format... 22574859 - The myxovirus-resistance protein, mx1, is a component of exosomes secreted by uterine e... 6688079 - Inhibition of dictyostelium discoideum differentiation in monolayers in vitro by endoge... 22760199 - Sensitization of glioma cells by x-linked inhibitor of apoptosis protein knockdown. 3009489 - In situ measurements of external ph and optical density oscillations in dictyostelium d... 18754999 - Imaging amoeboid cancer cell motility in vivo. 6095049 - Error-prone mutagenesis detected in mammalian cells by a shuttle vector containing the ... 3102559 - Sn-1,2-diacylglycerols and phorbol diesters stimulate thromboxane synthesis by de novo ... 8619229 - Comparative effects of cd2+ and cd-metallothionein on cultured kidney tubule cells. |
Publication Detail:
|
Type: Journal Article Date: 2011-02-24 |
Journal Detail:
|
Title: IUBMB life Volume: 63 ISSN: 1521-6551 ISO Abbreviation: IUBMB Life Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888706 Medline TA: IUBMB Life Country: England |
Other Details:
|
Languages: eng Pagination: 101-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
|
Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: miR-210: More than a silent player in hypoxia.
Next Document: Heparin plays a key regulatory role via a p53/FAK-dependent signaling in melanoma cell adhesion and ...