| MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells. | |
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MedLine Citation:
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PMID: 21550168 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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MicroRNA (miR)-143 and -145 were down-regulated in human bladder cancer T24 cells. The enforced expression of miR-143 induced growth-suppression in T24 cells through down-regulation of ERK5 and Akt expression at translational level, and chemically-modified synthetic miR-143 (miR-143/BP) exhibited a greater growth inhibitory effect than wild-type miR-143. In addition, the synthetic miR-143/BP induced apoptotic cell death in some of the transfected cells. Furthermore, co-treatment with the synthetic miR-143/BP and cisplatin showed the additive growth-suppressing effect on T24 cells. These findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in T24 cells by targeting ERK5 and/or Akt. |
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Authors:
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Syunsuke Noguchi; Takashi Mori; Yuki Hoshino; Kohji Maruo; Nami Yamada; Yukio Kitade; Tomoki Naoe; Yukihiro Akao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-5 |
Journal Detail:
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Title: Cancer letters Volume: - ISSN: 1872-7980 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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The United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu 501-1193, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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