Document Detail


MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines.
MedLine Citation:
PMID:  19540661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metastasis is a critical event in the progression of head and neck squamous cell carcinoma (HNSCC). To identify microRNAs associated with HNSCC metastasis, six paired HNSCC cell lines with different metastatic potential were examined. Using microarrays, a panel of differentially expressed microRNAs was identified, including reduction of miR-138 in highly metastatic cells. Ectopic transfection of miR-138 suppressed cell invasion and led to cell cycle arrest and apoptosis. Knockdown of miR-138 enhanced cell invasion and suppressed apoptosis. Thus, our results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis.
Authors:
Xiqiang Liu; Lu Jiang; Anxun Wang; Jinsheng Yu; Fei Shi; Xiaofeng Zhou
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2009-06-21
Journal Detail:
Title:  Cancer letters     Volume:  286     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-01-07     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
Carcinoma, Squamous Cell / genetics,  pathology
Cell Cycle
Cell Line, Tumor
Cell Movement
Flow Cytometry
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*
Head and Neck Neoplasms / genetics,  pathology
Humans
MicroRNAs / genetics*
Neoplasm Invasiveness
Neoplasm Metastasis
Oligonucleotide Array Sequence Analysis
Reverse Transcriptase Polymerase Chain Reaction
Transfection
Grant Support
ID/Acronym/Agency:
K22 DE014847/DE/NIDCR NIH HHS; K22 DE014847-05/DE/NIDCR NIH HHS; K22DE014847/DE/NIDCR NIH HHS; R01 CA139596/CA/NCI NIH HHS; R01 CA139596-01A2/CA/NCI NIH HHS; R01CA139596/CA/NCI NIH HHS; R03 CA135992/CA/NCI NIH HHS; R03 CA135992-01A1/CA/NCI NIH HHS; R03CA135992/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/MIRN138 microRNA, human; 0/MicroRNAs
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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