Document Detail


Micro-porous surfaces in controlled drug delivery systems: design and evaluation of diltiazem hydrochloride controlled porosity osmotic pump using non-ionic surfactants as pore-former.
MedLine Citation:
PMID:  23763379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The major problem associated with conventional drug delivery systems is unpredictable plasma concentrations. The aim of this study was to design a controlled porosity osmotic pump (CPOP) of diltiazem hydrochloride to deliver the drug in a controlled manner. CPOP tablets were prepared by incorporation of drug in the core and subsequent coating with cellulose acetate as semi-permeable membrane. Non-ionic surfactants were applied as pore-formers as well. The effect of pore-formers concentration on the in vitro release of diltiazem was also studied. The formulations were compared based on four comparative parameters, namely, total drug released after 24 h (D24 h), lag-time (tL), squared correlation coefficient of zero order equation (RSQzero) and mean percent deviation from zero order kinetic (MPDzero). Results of scanning electron microscopy studies exhibited formation of pores in the membrane from where the drug release occurred. It was revealed that drug release rate was directly proportional to the concentration of the pore-formers. The value of D24 h in the formulations containing Tween 80 (10%) and Brij 35 (5%) were found to be more than 94.9%, and drug release followed zero order kinetic (RSQzero > 0.99 and MPDzero < 8%) with acceptable tL (lower than 1 h).
Authors:
Khosro Adibkia; Saeed Ghanbarzadeh; Mohammad Hosein Shokri; Zahra Arami; Zeinab Arash; Javad Shokri
Related Documents :
23767079 - Orphan drug regulations. final rule.
24099399 - Nano-aggregates: emerging delivery tools for tumor therapy.
24135409 - The future of drug development and therapy in myeloma.
25107839 - (19)f applications in drug development and imaging - a review.
3746309 - Decision-making in refractory epilepsy: an analysis based on computer simulation.
22943119 - Clinical pharmacology confounders in older adults.
23909709 - Missed paracetamol (acetaminophen) overdose due to confusion regarding drug names.
3827719 - Multivesicular liposomes. sustained release of the antimetabolite cytarabine in the eye.
23165579 - Drug administration through feeding tubes: an integrated qualification program.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-13
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  -     ISSN:  1097-9867     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Drug Applied Research Center .
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An alternative short-form Mini-Nutritional Assessment for rating the risk of malnutrition in persons...
Next Document:  Serum autoantibodies positivity prevalence in patients with chronic HCV and impact on pegylated inte...