Document Detail

Micro-pattern-controlled local microtubule nucleation, transport and mesoscale organisation.
MedLine Citation:
PMID:  23294267     Owner:  NLM     Status:  Publisher    
Microtubule organisation in living cells is determined by spatial control of microtubule nucleation, their dynamic properties and transport by molecular motors. Here, we establish a new micro-pattern-guided method for controlling local microtubule nucleation by spatially confined immobilisation of a microtubule polymerase and show that these nucleated microtubules can be transported and organised in space by motor proteins. This assay provides a new platform for deciphering the principles underlying mesoscale microtubule organisation.
Surajit Ghosh; Christian Hentrich; Thomas Surrey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  ACS chemical biology     Volume:  -     ISSN:  1554-8937     ISO Abbreviation:  ACS Chem. Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282906     Medline TA:  ACS Chem Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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