Document Detail

Micro- and macrocirculatory, and biohumoral changes after a month of physical exercise in patients with intermittent claudication.
MedLine Citation:
PMID:  7569823     Owner:  NLM     Status:  MEDLINE    
We studied 15 subjects with intermittent claudication, classed as stage II according to Leriche-Fontaine. The patients were subjected to laser Doppler flowmetry, strain gauge plethysmography, Doppler velocimetry, and blood sampling, in basal conditions and after one month of physical training. Symptom-free walking distance at the end of the training period showed a significant increase, while there was no major change in maximal walking distance or the Windsor index. Laser Doppler flowmetry showed no significant change in cutaneous blood flow at rest, after the month of physical training. On the other hand, strain gauge plethysmography showed a significant decrease in rest flow at the end of the training period, while peak flow of postischemic hyperemia did not change appreciably. Biohumoral evaluations showed a significant decrease of white blood cell count, triglycerides and uric acid. Platelet count, prothrombin time, aPTT and plasminogen were unchanged. On the other hand, we recorded a small, but significant, rise of fibrinogen. Our study confirmed the importance of scheduled physical activity in the patient with intermittent claudication, showing that clinical improvement is not accompanied by an increase in the circulatory reserve. The unchanged levels of plasminogen suggest that the fibrinolytic activity does not vary significantly after a course of physical exercise.
P Pancera; M Prior; M Zannoni; L Lucchese; S De Marchi; E Arosio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rehabilitation medicine     Volume:  27     ISSN:  0036-5505     ISO Abbreviation:  Scand J Rehabil Med     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-26     Completed Date:  1995-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212503     Medline TA:  Scand J Rehabil Med     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Department of Rehabilitation, Valeggio sul Mincio Hospital, University of Verona, Italy.
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MeSH Terms
Aged, 80 and over
Blood Coagulation Tests
Exercise / physiology*
Intermittent Claudication / physiopathology*
Laser-Doppler Flowmetry
Leg / blood supply*
Leukocyte Count
Middle Aged
Regional Blood Flow
Triglycerides / blood
Uric Acid / blood
Reg. No./Substance:
0/Triglycerides; 69-93-2/Uric Acid

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