| A Micro-delivery Approach for Studying Microvascular Responses to Localized Oxygen Delivery. | |
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MedLine Citation:
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PMID: 21914035 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In vivo video microscopy has been used to study blood flow regulation as a function of varying oxygen concentration in microcirculatory networks. However, previous studies have measured the collective response of stimulating large areas of the microvascular network at the tissue surface. Objective: We aim to limit the area being stimulated by controlling oxygen availability to highly localized regions of the microvascular bed within intact muscle. Design and Method: Gas of varying O(2) levels was delivered to specific locations on the surface of the Extensor Digitorum Longus muscle of rat through a set of micro-outlets (100 μm diameter) patterned in ultrathin glass using state-of-the-art microfabrication techniques. O(2) levels were oscillated and digitized video sequences were processed for changes in capillary hemodynamics and erythrocyte O(2) saturation. Results and Conclusions: Oxygen saturations in capillaries positioned directly above the micro-outlets were closely associated with the controlled local O(2) oscillations. Radial diffusion from the micro-outlet is limited to ∼75 μm from the center as predicted by computational modelling and as measured in vivo. These results delineate a key step in the design of a novel micro-delivery device for controlled oxygen delivery to the microvasculature to understand fundamental mechanisms of microvascular regulation of O(2) supply. |
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Authors:
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Nour W Ghonaim; Leo W M Lau; Daniel Goldman; Christopher G Ellis; Jun Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-13 |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: - ISSN: 1549-8719 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons Ltd. |
Affiliation:
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Biomedical Engineering Graduate Program Surface Science Western Department of Chemistry Department of Medical Biophysics Department of Mechanical and Materials Engineering, The University of Western Ontario, London ON, Canada, N6A 3K7. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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