| Micro-computed tomography for analysis of urinary calculi. | |
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MedLine Citation:
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PMID: 20967434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Micro-computed tomographic (micro CT) imaging has become an important tool for the study of urinary stones. The method involves the collection of a series of X-ray pictures of the stone as it is rotated, and the internal structure of the stone is computationally reconstructed from these pictures. The entire process takes from 30 min to an hour with present technology. Resulting images of the stone provide unprecedented detail of the mineral composition and its morphological arrangement within the stone. For smaller stones, reconstructions can easily have voxel sizes of <5 μm, making this a truly microscopic view of the stone. The micro CT reconstructions can be viewed with any of a number of existing methods for visualizing the structure of both the surface and internal features of the stone. Because the entire process is non-destructive, traditional analysis methods--such as dissection and spectroscopic examination of portions of the stones--can also be performed. Micro CT adds value to traditional methods by identifying regions of the stone to be analyzed, and also with its ability to scan a cluster of stones or stone fragments at once. Finally, micro CT has become a powerful tool to help investigate events in stone formation that distinguish different kinds of stone disease. |
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Authors:
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James C Williams; James A McAteer; Andrew P Evan; James E Lingeman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-10-22 |
Journal Detail:
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Title: Urological research Volume: 38 ISSN: 1434-0879 ISO Abbreviation: Urol. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-25 Completed Date: 2011-03-11 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 0364311 Medline TA: Urol Res Country: Germany |
Other Details:
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Languages: eng Pagination: 477-84 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive MS 5055Y, Indianapolis, IN 46202-5120, USA. jwillia3@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Tomography, X-Ray Computed / methods* Urinary Calculi / chemistry*, etiology |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK565788/DK/NIDDK NIH HHS; R01 DK059933-08/DK/NIDDK NIH HHS; R01DK059933/DK/NIDDK NIH HHS; S10 RR023710/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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