Document Detail


Micro-assisted fertilization.
MedLine Citation:
PMID:  8711217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In couples who undergo routine in vitro fertilization (IVF), 17% experience significant problems with fertilization and many others are unable to have routine IVF because the quality of their semen is too poor. Often, the only options previously available to these couples were to use sperm donated by fertile men or to remain childless. Micromanipulative assisted fertilization techniques have improved the treatment of severe male factor infertility significantly and this paper provides a brief overview of the recent methodologies. Initially, techniques such as zona drilling and partial zona dissection, in which a hole or slit is placed in the zona pellucida, demonstrated that fertilization and pregnancies could be achieved with semen of very poor quality, but successes were sporadic. Later, subzonal injection of spermatozoa provided more consistent results with many units reporting pregnancies; however, relatively low rates of fertilization (14-34%) and high rates of polyspermy remained unresolved problems. The latest technique, the injection of a single spermatozoon into the oocyte cytoplasm, although technically difficult in animal models, proved to be highly successful in the human, restoring fertilization rates to those seen in routine IVF (65%) and producing good pregnancy rates from transferred embryos. Intracytoplasmic sperm injection has become the method of choice in the treatment of severe male factor infertility and preliminary data suggest that there is no increase in congenital abnormality among babies born after the transfer of injected oocytes.
Authors:
D Payne
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  7     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  1995  
Date Detail:
Created Date:  1996-09-06     Completed Date:  1996-09-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  831-9     Citation Subset:  IM    
Affiliation:
Reproductive Medicine Laboratories, University of Adelaide, Queen Elizabeth Hospital, Woodville, SA, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytoplasm
Female
Fertilization in Vitro*
Humans
Male
Microinjections
Micromanipulation / methods*
Pregnancy
Sperm-Ovum Interactions
Spermatozoa / ultrastructure
Zona Pellucida

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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