Document Detail


Micro-RNAs: New Regulators of Wound Healing.
MedLine Citation:
PMID:  22504970     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic wounds represent a significant burden to patients, health care professionals, and the health care system. Micro-RNAs (miRNAs) have recently emerged as a novel class of gene expression modulators involved in regulation of multiple biological processes, including development, differentiation, organogenesis, inflammation, cell proliferation, growth control, and apoptosis. Importantly, aberrant expression or activity of miRNAs can lead to a disease state. However, the role of miRNAs in chronic wounds remains to be elucidated. This article reviews available literature on the role of miRNAs in a range of processes important for successful wound healing including epidermal differentiation and proliferation, inflammation and angiogenesis. The potential role of miRNAs in normal wound healing and their contribution to chronic wound pathology has been anticipated. The prospective use of miRNAs as markers for surgical debridement, and as novel diagnostic and therapeutic targets for chronic wounds is also discussed.
Authors:
Irena Pastar; Horacio Ramirez; Olivera Stojadinovic; Harold Brem; Robert S Kirsner; Marjana Tomic-Canic
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-01
Journal Detail:
Title:  Surgical technology international     Volume:  XXI     ISSN:  1090-3941     ISO Abbreviation:  -     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-4-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604509     Medline TA:  Surg Technol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  51-60     Citation Subset:  -    
Affiliation:
Research Assistant Professor, Wound Healing and Regenerative Medicine Research Program, Department of Dermatology & Cutaneous Surgery, University of, Miami Miller School of Medicine, Miami, Florida.
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