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Micro-RNA expression in the urinary sediment of patients with chronic kidney diseases.
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MedLine Citation:
PMID:  22960330     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD.
METHODS: We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patients were followed for 16.2 ± 15.5 months.
RESULTS: Patients with diabetic glomerulosclerosis had lower urinary miR-15 expression, while those with IgA nephropathy had higher urinary miR-17 expression, than other diagnosis groups. Baseline proteinuria had significant inverse correlation with urinary expression of miR-15, miR-192, and miR-216a; baseline renal function correlated with urinary expression of miR-15, miR-17, miR-192, and miR-217. The rate of renal function decline correlated with urinary expression of miR-21 (r=0.301, p=0.026) and miR-216a (r=0.515, p < 0.0001). Patients with a high urinary expression of miR-21 and miR-216a had better dialysis-free survival than those with low expression (log rank test, p=0.005 and p=0.003, respectively).
CONCLUSIONS: Urinary miR-21 and miR-216a expression correlated with the rate of renal function decline and risk of progression to dialysis-dependent renal failure. Our results suggest that urinary miRNA profiling has the potential of further development as biomarkers of CKD.
Cheuk-Chun Szeto; Kwan Bonnie Ching-Ha; Lai Ka-Bik; Lai Fernand Mac-Moune; Choi Paul Cheung-Lung; Wang Gang; Chow Kai-Ming; Li Philip Kam-Tao
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  33     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-01-29     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
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MeSH Terms
Biological Markers / urine
Diabetic Nephropathies / diagnosis,  genetics,  urine
Gene Expression
Glomerulonephritis, IGA / diagnosis,  genetics,  urine
MicroRNAs / urine*
Middle Aged
Proteinuria / genetics,  urine
Renal Insufficiency, Chronic / diagnosis,  genetics,  urine*
Reg. No./Substance:
0/Biological Markers; 0/MIRN21 microRNA, human; 0/MIRN216 microRNA, human; 0/MicroRNAs

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2012 Hindawi Publishing Corporation.
Received Day: 30 Month: 7 Year: 2012
Accepted Day: 30 Month: 7 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 28 Month: 9 Year: 2012
Volume: 33 Issue: 3
First Page: 137 Last Page: 144
PubMed Id: 22960330
ID: 3810778
Article Id: 842764
DOI: 10.3233/DMA-2012-0914

Micro-RNA Expression in the Urinary Sediment of Patients with Chronic Kidney Diseases
Cheuk-Chun Szeto1*
Kwan Bonnie Ching-Ha1
Lai Ka-Bik1
Lai Fernand Mac-Moune2
Choi Paul Cheung-Lung2
Wang Gang1
Chow Kai-Ming1
Li Philip Kam-Tao1
1Department of Medicine & TherapeuticsPrince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina
2Department of Anatomical & Cellular PathologyPrince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina
Correspondence: *Cheuk-Chun Szeto:

Article Categories:
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Keywords: Proteinuria, glomerulonephritis, biomarker.

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