| Micro-RNA expression in the urinary sediment of patients with chronic kidney diseases. | |
| | |
MedLine Citation:
|
PMID: 22960330 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. Methods: We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patients were followed for 16.2 ± 15.5 months.Results: Patients with diabetic glomerulosclerosis had lower urinary miR-15 expression, while those with IgA nephropathy had higher urinary miR-17 expression, than other diagnosis groups. Baseline proteinuria had significant inverse correlation with urinary expression of miR-15, miR-192, and miR-216a; baseline renal function correlated with urinary expression of miR-15, miR-17, miR-192, and miR-217. The rate of renal function decline correlated with urinary expression of miR-21 (r=0.301, p=0.026) and miR-216a (r=0.515, p < 0.0001). Patients with a high urinary expression of miR-21 and miR-216a had better dialysis-free survival than those with low expression (log rank test, p=0.005 and p=0.003, respectively). Conclusions: Urinary miR-21 and miR-216a expression correlated with the rate of renal function decline and risk of progression to dialysis-dependent renal failure. Our results suggest that urinary miRNA profiling has the potential of further development as biomarkers of CKD. |
| | |
Authors:
|
Cheuk-Chun Szeto; Kwan Bonnie Ching-Ha; Lai Ka-Bik; Lai Fernand Mac-Moune; Choi Paul Cheung-Lung; Wang Gang; Chow Kai-Ming; Li Philip Kam-Tao |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-9 |
Journal Detail:
|
Title: Disease markers Volume: - ISSN: 1875-8630 ISO Abbreviation: Dis. Markers Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma C-reactive protein is not related to sinus non-conversion by maze procedure adjunct to mitral...
Next Document: DJ-1 variants in Indian Parkinson's disease patients.