| Miconazole in the treatment of chronic mucocutaneous candidiasis: a preliminary report. | |
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MedLine Citation:
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PMID: 909025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Miconazole, a new imidazole antimycotic agent, was given intravenously to five children with chronic mucocutaneous candidiasis over an 18-month period. There was marked improvement of mucosa and skin in two patients, moderate-to-milk improvement in two, and no improvement in one. Nail lesions were not improved in any patient. Adverse reactions included phlebitis, pruritus, nausea and dizziness, rash, wheezing, mild transient anemia, and mild transient transaminase (SGOT and SGPT) elevations; it was necessary to discontinue treatment in only one patient. No renal toxocity was noted. Miconazole appears to be a relatively safe and promising alternative to amphotericin B in chronic mucocutaneous candidiasis. |
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Authors:
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T J Fischer; R B Klein; H E Kershnar; T C Borut; E R Stiehm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 91 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1977 Nov |
Date Detail:
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Created Date: 1977-11-30 Completed Date: 1977-11-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 815-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Candidiasis, Cutaneous / drug therapy* Child Child, Preschool Chronic Disease Female Humans Imidazoles / therapeutic use* Infant Infusions, Parenteral Male Miconazole / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 22916-47-8/Miconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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