Document Detail


Micelles of poly(ethylene oxide)-block-poly(N-alkyl stearate L-aspartamide): synthetic analogues of lipoproteins for drug delivery.
MedLine Citation:
PMID:  11033567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stearic acid esters of poly(ethylene oxide)-block-poly(hydroxyethyl L-aspartamide) and poly(ethylene oxide)-block-poly(hydroxyhexyl L-aspartamide) have been synthesized from poly(ethylene oxide)-block-poly(beta-benzyl L-aspartate) by polymer-analogous reactions and self-assembled into a micelle. Transmission electron microscopy and fluorescent probe studies reveal that the micelle mimics structural features of serum lipoproteins: it is nanoscopic, spherical, and has a supramolecular core-shell architecture, where the core is rich in fatty acid esters. As a result, the polymeric micelles effectively solubilize amphotericin B, a key drug for systemic mycoses. Serum lipoproteins solubilize many hydrophobic drugs as a biological transport system besides amphotericin B. A synthetic polymeric analogue may achieve the same aim, but with the ease of structural modification, safety, and stability.
Authors:
A Lavasanifar; J Samuel; G S Kwon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  52     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-5     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Affiliation:
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amphotericin B / administration & dosage,  chemistry
Aspartic Acid
Biopolymers
Drug Carriers
Fluorescent Dyes
Lipoproteins / chemistry
Micelles*
Microscopy, Electron
Molecular Structure
Polyesters / administration & dosage,  chemical synthesis,  chemistry*
Polyethylene Glycols / administration & dosage,  chemical synthesis,  chemistry*
Proteins / administration & dosage,  chemical synthesis,  chemistry*
Solubility
Grant Support
ID/Acronym/Agency:
AI 43346-01/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Biopolymers; 0/Drug Carriers; 0/Fluorescent Dyes; 0/Lipoproteins; 0/Micelles; 0/Polyesters; 0/Polyethylene Glycols; 0/Proteins; 0/poly(ethylene oxide)-block-poly(N-ethyl stearate) aspartamide; 0/poly(ethylene oxide)-block-poly(N-hexyl stearate) aspartamide; 0/poly(ethylene oxide)-block-poly(beta-benzyl aspartate); 1397-89-3/Amphotericin B; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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