| Micelles of poly(ethylene oxide)-block-poly(N-alkyl stearate L-aspartamide): synthetic analogues of lipoproteins for drug delivery. | |
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MedLine Citation:
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PMID: 11033567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stearic acid esters of poly(ethylene oxide)-block-poly(hydroxyethyl L-aspartamide) and poly(ethylene oxide)-block-poly(hydroxyhexyl L-aspartamide) have been synthesized from poly(ethylene oxide)-block-poly(beta-benzyl L-aspartate) by polymer-analogous reactions and self-assembled into a micelle. Transmission electron microscopy and fluorescent probe studies reveal that the micelle mimics structural features of serum lipoproteins: it is nanoscopic, spherical, and has a supramolecular core-shell architecture, where the core is rich in fatty acid esters. As a result, the polymeric micelles effectively solubilize amphotericin B, a key drug for systemic mycoses. Serum lipoproteins solubilize many hydrophobic drugs as a biological transport system besides amphotericin B. A synthetic polymeric analogue may achieve the same aim, but with the ease of structural modification, safety, and stability. |
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Authors:
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A Lavasanifar; J Samuel; G S Kwon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 52 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-01 Completed Date: 2000-12-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 831-5 Citation Subset: IM |
Copyright Information:
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Copyright 2000 John Wiley & Sons, Inc. |
Affiliation:
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Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2N8, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
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administration & dosage,
chemistry Aspartic Acid Biopolymers Drug Carriers Fluorescent Dyes Lipoproteins / chemistry Micelles* Microscopy, Electron Molecular Structure Polyesters / administration & dosage, chemical synthesis, chemistry* Polyethylene Glycols / administration & dosage, chemical synthesis, chemistry* Proteins / administration & dosage, chemical synthesis, chemistry* Solubility |
| Grant Support | |
ID/Acronym/Agency:
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AI 43346-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biopolymers; 0/Drug Carriers; 0/Fluorescent Dyes; 0/Lipoproteins; 0/Micelles; 0/Polyesters; 0/Polyethylene Glycols; 0/Proteins; 0/poly(ethylene oxide)-block-poly(N-ethyl stearate) aspartamide; 0/poly(ethylene oxide)-block-poly(N-hexyl stearate) aspartamide; 0/poly(ethylene oxide)-block-poly(beta-benzyl aspartate); 1397-89-3/Amphotericin B; 56-84-8/Aspartic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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