Document Detail


Micellar electrokinetic chromatography: A practical overview of current methodological and instrumental advances.
MedLine Citation:
PMID:  21110329     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This review highlights recent methodological and instrumental advances in MEKC focused on the improvement of this CE technique in routine analyses. As in the previous reviews, the present one deals with the last 2 years' most relevant methodological contributions for improving sensitivity and resolution in MEKC as well as instrumental research related to MS and LIF detection. The most widespread approaches are discussed in detail, including enhancements in sensitivity arising from the use of on-line sample concentration (stacking, sweeping, and a combination of both of these protocols) and improvements in resolution, obtained by changing the composition of the BGE (e.g. with additives to the aqueous phase or employing alternative micellar phases to classical SDS) and using 2-D separation systems. The advantages and restrictions in MS and LIF detection as applied to MEKC analysis are also examined, especially in the direct coupling of MEKC and MS detection. Finally, some thoughts on potential future directions are also considered.
Authors:
Manuel Silva
Related Documents :
11465499 - Micellar electrokinetic capillary chromatography for the determination of viagra and it...
11746239 - Determination of bisphenol a and 10 alkylphenols in serum using sds micelle capillary e...
11382289 - Determination of 5-aminosalicylic acid related impurities by micellar electrokinetic ch...
23398889 - Lc-ms/apci identification of glucoside esters and diesters of astaxanthin from the snow...
20875579 - On-line concentration and determination of tobacco-specific n-nitrosamines by cation-se...
10546829 - Determination of chlorophenols in human urine based on the integration of on-line autom...
20433069 - Chemical composition and bioactivity of pleiogynium timorense (anacardiaceae).
19922939 - Light emitting diode induced chemiluminescence and its application as a detector for hi...
23281329 - A rapid and simple separation and direct detection of glutathione by gold nanoparticles...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-25
Journal Detail:
Title:  Electrophoresis     Volume:  -     ISSN:  1522-2683     ISO Abbreviation:  -     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8204476     Medline TA:  Electrophoresis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Analytical Chemistry, University of Cordoba, Cordoba, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Augmented p-rep designs.
Next Document:  Recent advances in the MS analysis of glycoproteins: Capillary and microfluidic workflows.