| Micellar electrokinetic chromatography for determination of drug partition in phospholipids. | |
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MedLine Citation:
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PMID: 15652373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lipophilicity of pipemidic, nalidixic and oxolinic acids was determined by forming phospholipidic micelles directly in an electrophoretic capillary. Phosphatidylcholine derivatives, namely L-alpha-dilauroyl phosphatidylcholine (DLPC) or L-alpha-dimiristoyl phosphatidylcholine (DMPC), were added in the run buffer (50 mM phosphate buffer at pH 7.4). To obtain a mixed micelle, phospholipidic derivatives and sodium cholate were together added in the run buffer. Considering the increasing of migration time when phosphatidylcholine derivative is added in the run buffer, Ks can be determined and then quinolones lipophilicity. |
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Authors:
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M G Quaglia; S Fanali; F Barbato; E Donati |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-24 |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 60 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: Italy |
Other Details:
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Languages: eng Pagination: 77-83 Citation Subset: IM |
Affiliation:
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Dipartimento Studi Farmaceutici, Università degli Studi La Sapienza di Roma, P.le A. Moro 5-00185 Roma, Italy. mariagiovanna.quaglia@uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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analysis,
chemistry* Chromatography, Micellar Electrokinetic Capillary / methods* Nalidixic Acid / analysis, chemistry* Oxolinic Acid / analysis, chemistry* Phospholipids / analysis, chemistry* Pipemidic Acid / analysis, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Phospholipids; 14698-29-4/Oxolinic Acid; 389-08-2/Nalidixic Acid; 51940-44-4/Pipemidic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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