Document Detail


Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine.
MedLine Citation:
PMID:  18560807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: The 5-HT transporter (5-HTT) is implicated in the regulation of appetite. Expression of the 5-HTT varies in the human population, and this variation may determine both individual differences in feeding and abnormal feeding behaviours such as eating disorders.
OBJECTIVES: The effects of 5-HTT expression on feeding and satiety were examined in a transgenic mouse model of 5-HTT overexpression.
MATERIALS AND METHODS: We measured free-feeding food intake and observed the behavioural satiety sequence (BSS) after food deprivation in mice at baseline and after administration of the anorectic drug fenfluramine.
RESULTS: 5-HTT overexpressing mice were both lighter and shorter than their wildtype littermates. Despite this size difference, food intake by transgenic and wildtype mice did not differ. There was no effect of genotype on the BSS or on food intake during the test at baseline. Increasing doses of fenfluramine reduced food intake in a similar manner in both transgenic and wildtype mice. After 0.3 and 1 mg/kg fenfluramine, the temporal pattern of the BSS was the same for both groups, whereas 3 and 10 mg/kg fenfluramine disrupted the BSS. In transgenic mice, this disruption was evident at the 3 mg/kg dose, while in wildtypes, it emerged only at the 10-mg/kg dose.
CONCLUSION: These data suggest that overexpression of the 5-HTT does not lead to alterations in feeding or satiety in food-deprived mice but does increase the occurrence of other non-feeding behaviours in response to the 5-HT releasing agent fenfluramine.
Authors:
A Pringle; K A Jennings; S Line; D M Bannerman; S Higgs; T Sharp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-16
Journal Detail:
Title:  Psychopharmacology     Volume:  200     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2009-01-29     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Fenfluramine / administration & dosage,  pharmacology*
Gene Expression
Genotype
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Satiety Response / drug effects
Serotonin Agents / administration & dosage,  pharmacology*
Serotonin Plasma Membrane Transport Proteins / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
087736//Wellcome Trust; //Medical Research Council
Chemical
Reg. No./Substance:
0/Serotonin Agents; 0/Serotonin Plasma Membrane Transport Proteins; 2DS058H2CF/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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