| Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. | |
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MedLine Citation:
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PMID: 10600477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. To investigate the function of Pin1 in mammalian cells, we created mice lacking Pin1. These mice underwent normal development. Although the embryonic Pin1-/- fibroblasts grew normally, they proved significantly deficient in their ability to restart proliferation in response to serum stimulation after G(0) arrest. These results suggest that Pin1 is required for cell cycle progression from G(0) arrest as well as mitosis progression in normal mammalian cells. |
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Authors:
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F Fujimori; K Takahashi; C Uchida; T Uchida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 265 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-11 Completed Date: 2000-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 658-63 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Academic Press. |
Affiliation:
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GeneSurf, Advanced Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AB009691; AB009692 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Cell Cycle / genetics, physiology* Cell Division / genetics, physiology Cloning, Molecular DNA Primers / genetics DNA, Complementary / genetics Exons Female G0 Phase / genetics, physiology Introns Male Mice Mice, Knockout Molecular Sequence Data Peptidylprolyl Isomerase / deficiency*, genetics, physiology Phenotype Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/DNA, Complementary; 0/NIMA-interacting peptidylprolyl isomerase; EC 5.2.1.8/Peptidylprolyl Isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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