Document Detail


Of Mice and Children: Lessons from a Kawasaki Mouse Model.
MedLine Citation:
PMID:  22361327     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Despite 50 years of research, the etiology of Kawasaki disease (KD), the most common cause of acquired heart disease in children, remains a mystery. Fueled by epidemiologic and clinical clues that the disease was triggered by an infectious agent that elicited a dramatic immune response in genetically susceptible children, investigators vigorously searched for the responsible agent(1). Thus far, a long list of discarded pathogens is all that remains of these attempts to find the inflammation-causing agent. Application of reverse genetics to engineer synthetic antibodies to track down a putative new virus has shown some promise, but the agent still remains elusive(2). (SELECT FULL TEXT TO CONTINUE).
Authors:
Jane C Burns
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-23
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
UCSD School of Medicine & Rady Children's Hospital San Diego, La Jolla, CA.
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