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Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants.
MedLine Citation:
PMID:  23773357     Owner:  NLM     Status:  Publisher    
OBJECTIVE: We conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low birth weight (ELBW) infants who were born at a gestational age of less than 26 weeks and weighed less than 1,000 g. STUDY DESIGN: With a combination of enteral administration of miconazole (6 mg/kg/day), FLCZ and MCFG were administered intravenously at a dose of 5 mg/kg/day (FLCZ) and 3 mg/kg/day (MCFG), respectively. The prophylaxis was classified as a failure when fungal infections were identified within the first 21 days after birth. RESULTS: The prophylaxis was successful in 7 of 18 cases (39%) in the FLCZ group and 15 of 21 cases (71%) in the MCFG group, indicating that the success rate was significantly higher in the latter group. CONCLUSION: MCFG was superior to FLCZ as prophylaxis against fungal infections in ELBW infants.
Yoshinobu Maede; Satoshi Ibara; Hiraku Nagasaki; Takeshi Inoue; Takuya Tokuhisa; Motofumi Torikai; Chie Ishihara; Takako Matsui; Yuichi Kodaira
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-17
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Department of Neonatology, Perinatal Medical Center, Kagoshima City Hospital, 20-17, Kajiya-cho, Kagoshima, Kagoshima 892-8580, Japan.
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