Document Detail


Mib-1 proliferation index is an independent predictor of lymph node metastasis in invasive breast cancer: a prospective study on 675 patients.
MedLine Citation:
PMID:  16391864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to evaluate the potential risk factors for lymph node metastasis in invasive breast cancer patients submitted to axillary dissection, 675 patients who received surgery between January 1995 and December 2002 were included in a prospective study. In all cases, MIB-1 proliferation index was investigated by immunohistochemistry. Lymph node involvement was found in 248 out of 675 patients. Univariate analysis showed that peritumoral lymphovascular invasion, pT stage, tumor multiplicity, MIB-1 proliferation index >10%, oestrogen receptor status, histological type, tumor grade and progesterone receptor status were related to a higher incidence of lymph node metastasis, with various levels of statistical significance. Multivariate analysis identified lymphovascular invasion [relative risk (RR, 7.69; p<0.001), pT stage (RR, 3.08; p<0.001), tumor multiplicity (RR, 3.89; p<0.001), and MIB-1 proliferation index (RR, 1.66; p=0.019)] as independent predictive variables. The impact of MIB-1 positivity on the incidence of lymph node metastasis was particularly evident in intermediate risk groups (pT1c, pT2 without lymphovascular invasion), as well as in grade-2 tumors. In conclusion, the MIB-1 proliferation index could provide additional information about the risk of lymph node metastasis in invasive breast cancer, and may be useful to identify grade-2 tumors with a more aggressive clinical behaviour.
Authors:
Daniele Marrelli; Enrico Pinto; Alessandro Neri; Tiziana Megha; Walter Gioffrè; Tommaso Cioppa; Giovanni De Marco; Alfonso De Stefano; Franco Roviello
Related Documents :
12866574 - Prediction of lymph node metastasis by p53, p21(waf1), and pcna expression in esophagea...
15783374 - Weight-driven growing networks.
7456174 - The prognostic role of lymphadenectomy in adenocarcinoma of the prostate.
20087614 - Advanced carcinoma of the prostatic urethra in a patient with marked response to chemot...
7426564 - Preinvasive carcinoma of the cornea and conjunctiva.
17943724 - Chromosomal deletion, promoter hypermethylation and downregulation of fyn in prostate c...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  15     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
Affiliation:
Department of General Surgery, University of Siena, Viale Bracci, 53100 Siena, Italy. Marrelli@unisi.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms / metabolism*,  pathology*,  surgery
Cell Proliferation
Female
Humans
Immunohistochemistry
Ki-67 Antigen / metabolism*
Lymphatic Metastasis / pathology*
Middle Aged
Neoplasm Staging
Prognosis
Prospective Studies
Receptors, Estrogen / metabolism
Receptors, Progesterone / metabolism
Risk Factors
Tumor Markers, Biological / analysis*
Chemical
Reg. No./Substance:
0/Ki-67 Antigen; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro effects on proliferation, apoptosis and colony inhibition in ER-dependent and ER-independen...
Next Document:  Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial...