Document Detail


MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.
MedLine Citation:
PMID:  22898998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: These results indicate that miRNA-140 acts as a liver tumor suppressor, and that impairment of miRNA-140 function due to a deficiency of DDX20, a miRNA machinery component, could lead to hepatocarcinogenesis.
Authors:
Akemi Takata; Motoyuki Otsuka; Takeshi Yoshikawa; Takahiro Kishikawa; Yohko Hikiba; Shuntaro Obi; Tadashi Goto; Young Jun Kang; Shin Maeda; Haruhiko Yoshida; Masao Omata; Hiroshi Asahara; Kazuhiko Koike
Related Documents :
11389538 - Subnuclear dynamics and transcription factor function.
19345088 - Replication timing and transcriptional control: beyond cause and effect--part ii.
16788068 - Recruitment of mrna cleavage/polyadenylation machinery by the yeast chromatin protein s...
11358958 - Rack1 interacts with e1a and rescues e1a-induced yeast growth inhibition and mammalian ...
11880228 - The expression system of biologically active canine interleukin-8 in leishmania promast...
12571248 - Yy1 transcription factor down-regulates expression of ccr5, a major coreceptor for hiv-1.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-03-04     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Hepatocellular / metabolism*
Cell Line, Tumor
DEAD Box Protein 20 / metabolism*
DNA (Cytosine-5-)-Methyltransferase / metabolism*
Hep G2 Cells
Humans
Liver Neoplasms / metabolism*
Metallothionein / metabolism
Mice
Mice, Knockout
MicroRNAs / metabolism*
NF-kappa B / metabolism*
Tumor Suppressor Proteins / metabolism
Grant Support
ID/Acronym/Agency:
R01 AI088229/AI/NIAID NIH HHS; R01AI088229/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/Mirn140 microRNA, human; 0/NF-kappa B; 0/Tumor Suppressor Proteins; 9038-94-2/Metallothionein; EC 2.1.1.37/DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37/DNA (cytosine-5-)-methyltransferase 1; EC 3.6.1.-/DDX20 protein, human; EC 3.6.1.-/DEAD Box Protein 20
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  IN VITRO ANTIVIRAL ACTIVITY OF AN ALKALINE TRYPSIN FROM THE DIGESTIVE JUICE OF Bombyx mori LARVAE AG...
Next Document:  Passive heat exposure induced by hot water leg immersion increased oxyhemoglobin in pre-frontal cort...