Document Detail


MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.
MedLine Citation:
PMID:  22673513     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled. Here, we describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux. These findings have not only figured out an alternative mechanism for LXR regulation, but also provided a potential therapeutic target for cholesterol metabolic disorders.
Authors:
Dongsheng Sun; Jun Zhang; Jianhong Xie; Wei Wei; Mantao Chen; Xiang Zhao
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Publication Detail:
Type:  Journal Article     Date:  2012-04-18
Journal Detail:
Title:  FEBS letters     Volume:  586     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1472-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Geriatrics, Zhejiang Provincial People's Hospital, Hangzhou, PR China.
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