| MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis. | |
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MedLine Citation:
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PMID: 22417311 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MicroRNAs are short non-coding RNAs that regulate gene expression. Previously, in a genome-wide screen, we found deregulation of microRNA expression in psoriasis skin. MicroRNA-21 (miR-21) is one of the microRNAs significantly up-regulated in psoriasis skin lesions. To identify the cell type responsible for the increased miR-21 level, we compared expression of miR-21 in epidermal cells and dermal T cells between psoriasis and healthy skin and found elevated levels of miR-21 in psoriasis in both cell types. In cultured T cells, expression of miR-21 increased markedly upon activation. To explore the function of miR-21 in primary human T helper cells, we inhibited miR-21 using a tiny seed-targeting LNA-anti-miR. Specific inhibition of miR-21 increased the apoptosis rate of activated T cells. Our results suggest that miR-21 suppresses apoptosis in activated T cells, and thus, overexpression of miR-21 may contribute to T cell-derived psoriatic skin inflammation. |
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Authors:
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Florian Meisgen; Ning Xu; Tianling Wei; Peter C Janson; Susanna Obad; Oliver Broom; Nikoletta Nagy; Sakari Kauppinen; Lajos Kemény; Mona Ståhle; Andor Pivarcsi; Enikö Sonkoly |
Publication Detail:
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Type: Letter |
Journal Detail:
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Title: Experimental dermatology Volume: 21 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 312-4 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Dermatology and Venereology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Unit of Clinical Allergy Research, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Santaris Pharma A/S, Hørsholm, Denmark Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Copenhagen Institute of Technology, Aalborg University, Denmark. |
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