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MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.
MedLine Citation:
PMID:  22417311     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MicroRNAs are short non-coding RNAs that regulate gene expression. Previously, in a genome-wide screen, we found deregulation of microRNA expression in psoriasis skin. MicroRNA-21 (miR-21) is one of the microRNAs significantly up-regulated in psoriasis skin lesions. To identify the cell type responsible for the increased miR-21 level, we compared expression of miR-21 in epidermal cells and dermal T cells between psoriasis and healthy skin and found elevated levels of miR-21 in psoriasis in both cell types. In cultured T cells, expression of miR-21 increased markedly upon activation. To explore the function of miR-21 in primary human T helper cells, we inhibited miR-21 using a tiny seed-targeting LNA-anti-miR. Specific inhibition of miR-21 increased the apoptosis rate of activated T cells. Our results suggest that miR-21 suppresses apoptosis in activated T cells, and thus, overexpression of miR-21 may contribute to T cell-derived psoriatic skin inflammation.
Authors:
Florian Meisgen; Ning Xu; Tianling Wei; Peter C Janson; Susanna Obad; Oliver Broom; Nikoletta Nagy; Sakari Kauppinen; Lajos Kemény; Mona Ståhle; Andor Pivarcsi; Enikö Sonkoly
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Experimental dermatology     Volume:  21     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  312-4     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Dermatology and Venereology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Unit of Clinical Allergy Research, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Santaris Pharma A/S, Hørsholm, Denmark Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary Copenhagen Institute of Technology, Aalborg University, Denmark.
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