Document Detail


Mevalonic acid is partially synthesized from amino acids in Halobacterium cutirubrum: a 13C nuclear magnetic resonance study.
MedLine Citation:
PMID:  3700337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
13C nuclear magnetic resonance revealed an unusual pathway for the biosynthesis of lipids in Halobacterium cutirubrum and H. halobium. Mevalonic acid was not synthesized from three acetyl-coenzyme A molecules, as has been suggested previously, and the branch-methyl and methine carbons in phytanyl chains were derived from neither acetate nor glycerol. Instead, they were supplied by the degradation of amino acids, in particular of lysine. Presumably, two different types of two-carbon fragments were used simultaneously by halobacteria for the biosynthesis of mevalonate. The labeling pattern of squalene supported the above conclusions. Based on these data, a general scheme is proposed to account for the contribution of lysine-to-lipid biosynthesis.
Authors:
I Ekiel; G D Sprott; I C Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  166     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-20     Completed Date:  1986-06-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid
Acetic Acids / metabolism
Acetyl Coenzyme A / metabolism
Amino Acids / metabolism*
Glycerol / metabolism
Halobacterium / metabolism*
Lipid Metabolism
Magnetic Resonance Spectroscopy
Mevalonic Acid / biosynthesis*
Models, Molecular
Chemical
Reg. No./Substance:
0/Acetic Acids; 0/Amino Acids; 150-97-0/Mevalonic Acid; 56-81-5/Glycerol; 64-19-7/Acetic Acid; 72-89-9/Acetyl Coenzyme A
Comments/Corrections

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