| Mevalonate metabolism by renal tissue in vitro. | |
| | |
MedLine Citation:
|
PMID: 4811213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid. Kidneys, however, convert mevalonic acid primarily to the precursors of cholesterol, squalene and lanosterol, rather than to cholesterol. This study was designed to define the specific tissue site within the kidney responsible for mevalonic acid metabolism. Tissue slices from rat and dog renal cortex and medulla and glomeruli and tubules were isolated, and the incorporation of (14)C-labeled mevalonic acid into the nonsaponifiable lipids squalene, lanosterol, and cholesterol was determined in these tissues. The results demonstrate that the renal cortex is the primary site of mevalonic acid metabolism within the kidney and that the glomerulus is responsible for 95% of the mevalonic acid metabolized by the renal cortex. As was the case for the whole kidney, the major metabolites of mevalonate in the glomeruli are squalene and lanosterol. |
| | |
Authors:
|
P Raskin; M D Siperstein |
Related Documents
:
|
8835403 - Stearic acid unlike shorter-chain saturated fatty acids is poorly utilized for triacylg... 575293 - Variations in the total sterols, free sterols and sterol esters concentration during em... 164943 - Lipoprotein-acid mucopolysaccharide complexes of human atherosclerotic lesions. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of lipid research Volume: 15 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1974 Jan |
Date Detail:
|
Created Date: 1974-03-28 Completed Date: 1974-03-28 Revised Date: 2007-03-21 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 20-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetates
/
metabolism Animals Carbon Radioisotopes Cholesterol / biosynthesis Chromatography, Thin Layer Dogs Female Kidney / metabolism* Kidney Cortex / metabolism Kidney Glomerulus / metabolism Kidney Medulla / metabolism Kidney Tubules / metabolism Kinetics Lanosterol / biosynthesis Lipids / biosynthesis Mevalonic Acid / metabolism* Rats Squalene / biosynthesis |
| Chemical | |
Reg. No./Substance:
|
0/Acetates; 0/Carbon Radioisotopes; 0/Lipids; 111-02-4/Squalene; 150-97-0/Mevalonic Acid; 57-88-5/Cholesterol; 79-63-0/Lanosterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Some properties of the PBP1 transduction system in Bacillus pumilus.
Next Document: Incorporation of (2-3H)glycerol into rat brain 1,2-diacyl-sn-glycero-3-phosphorylcholine and 1,2-dia...