Document Detail

Mevalonate metabolism by renal tissue in vitro.
MedLine Citation:
PMID:  4811213     Owner:  NLM     Status:  MEDLINE    
Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid. Kidneys, however, convert mevalonic acid primarily to the precursors of cholesterol, squalene and lanosterol, rather than to cholesterol. This study was designed to define the specific tissue site within the kidney responsible for mevalonic acid metabolism. Tissue slices from rat and dog renal cortex and medulla and glomeruli and tubules were isolated, and the incorporation of (14)C-labeled mevalonic acid into the nonsaponifiable lipids squalene, lanosterol, and cholesterol was determined in these tissues. The results demonstrate that the renal cortex is the primary site of mevalonic acid metabolism within the kidney and that the glomerulus is responsible for 95% of the mevalonic acid metabolized by the renal cortex. As was the case for the whole kidney, the major metabolites of mevalonate in the glomeruli are squalene and lanosterol.
P Raskin; M D Siperstein
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  15     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1974 Jan 
Date Detail:
Created Date:  1974-03-28     Completed Date:  1974-03-28     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  IM    
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MeSH Terms
Acetates / metabolism
Carbon Radioisotopes
Cholesterol / biosynthesis
Chromatography, Thin Layer
Kidney / metabolism*
Kidney Cortex / metabolism
Kidney Glomerulus / metabolism
Kidney Medulla / metabolism
Kidney Tubules / metabolism
Lanosterol / biosynthesis
Lipids / biosynthesis
Mevalonic Acid / metabolism*
Squalene / biosynthesis
Reg. No./Substance:
0/Acetates; 0/Carbon Radioisotopes; 0/Lipids; 111-02-4/Squalene; 150-97-0/Mevalonic Acid; 57-88-5/Cholesterol; 79-63-0/Lanosterol

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